Melihat calon lawan di atas, Atletico berpotensi besar akan menghadapi lawan kuat di babak 16 besar. Karena itu, pelatih Atletico Diego Simeone harus putar otak untuk menghadapi fase knockout Liga Champions 2018-2019.
Berikut calon lawan kontestan 16 besar Liga Champions 2018-2019:
Borussia Dortmund = Ajax, Liverpool, Lyon, Man. United, Roma, Tottenham
Barcelona = Ajax, Liverpool, Lyon, Man. United, Roma, Schalke
Paris Saint-Germain = Ajax, Atlético, Man. United, Roma, Schalke, Tottenham
FC Porto = Ajax, Atletico, Liverpool, Lyon, Man. United, Roma, Tottenham
Bayern Munich = Atletico, Liverpool, Lyon, Man. United, Roma, Tottenham
